Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor

Background and Objectives: Coronavirus 2019 (Covid-19) has become a global disease that can affect various organs of the human body. Kidney disorders are the most common disorders in patients with Covid-19. Kidney involvement manifests as proteinuria and acute kidney injury (AKI). This virus can cause acute tubular necrosis, protein leakage in the Bowman's capsule, glomerulopathy, and mitochondrial dysfunction via angiotensin-converting enzyme 2 (ACE2). It can also interfere with the regulation of immune responses (including cytokine storm), unbalanced activation of the renin-angiotensin system, and unbalanced activation of macrophages in the kidneys. To date, there is no specific treatment strategy to protect the kidneys against Covid-19. Therefore, considering the vital role of the kidneys in maintaining body homeostasis, it is suggested that special attention be paid to this organ during the treatment of patients with Covid-19. Key words: Covid-19 disease, Acute kidney injury, Inflammation, Immune response, Renin-angiotensin system Funding: None. Conflict of interest: None declared. Ethical approval: None declared. How to cite this article: Kaeidi A, Hassanshahi J. Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor. J Rafsanjan Univ Med Sci 2022; 20 (12): 1385-90 [Fars